Human Stem Cell Biology Diagrams The cell-cycle state of stem cells determines cell fate propensity. Cell 155 , 135-147 (2013). Article CAS PubMed PubMed Central Google Scholar
Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of … The unusual cell cycle properties of ESCs change upon dissolution of pluripotency, when stem cells undergo cell fate specification and differentiate into different lineages 16,. During this process, cell division length increases, mainly due to an expanded G1 phase 16 , 24 , 28 , 34 , 43 , 58 .
Cell Cycle Rules Pluripotency: Cell Stem Cell Biology Diagrams
Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our curre … (a) Stem cells exposed to cell fate specification cues differentiate as an asynchronous wave.(b) The asynchronous differentiation program can be accounted for by the activation of developmental genes in G1-phase of the cell cycle. Cells in G1 respond rapidly to differentiation cues whereas cells in S-, G2-and M-phase experience a delay, indicated by the kinetics of transcriptional activation.
Pluripotency is also linked with cell-cycle regulation because studies in mouse ESCs (mESCs) have shown that their pluripotent status is associated with a specific cell-cycle profile characterized by a shortened G1 phase and the lack of G1 checkpoint regulation (Coronado et al., 2013; Savatier et al., 1996).In conventional cells, cyclin D1-3 are expressed in G1 phase and control the activity
Cell cycle dynamics of mouse embryonic stem cells in the ... Biology Diagrams
The cell-cycle state of stem cells determines cell fate propensity. Cell 155, 135-47 (2013). Article CAS Google Scholar Singh, A. M. et al. Cell-Cycle Control of Developmentally Regulated
